Monoclonal antibodies against meningococcal polysaccharide with cross-reactivity against brain antigens

discrete staining of cell bodies was found with type I sera in the newborn or 5-day-old rats. In the newborn there was a diffuse staining of the parenchyma of the developing cortex and other areas. Type I1 staining was observed, particularly in those cells with developed perikarya. By 9 days type I sera began to show, although only weakly, some cells in the cortex and hippocampus. At 14 days some of the cells in the dentate nucleus began to show type I staining, and by 21 days the staining pattern was as in the adult brain. Sera giving type I1 pattern of staining did so at all ages examined. One of the sera, which normally gave type I staining with adult brain, gave additional type I1 staining in the young brains. Braun, P., Frail, D. & Latov, N. (1982) J . Neurochivn. 39, 1261.1265 Denton, C. P., Gregson, N. A,. Leibowitz. S. & Kennedy, M. L. (1984) Brain Res. 295, 348-351 Ilyas, A. A,, Quarles, R. H., Maclntosh, T. T., Dobersen, M. J., Trapp, B. D., Dalakas, M. C. & Brady, R. 0. (1984) Proc. Narl. Acad. Sci. U.S.A. 81, 1225-1229 Latov, N., Sherman, W. H., Nemni, R., Galassi, G . , Shyong, J . S., Penn, A. S., Chess, L., Olarte, M. R., Rowland, L. P. & Osserman, E. F. (1980) N . Eng. J. M e d . 303, 618-662 Leibowitz, S., Gregson, N. A,, Kennedy, M. & Kalm, S. (1983)J. Neurol. Sci. 59, 153-165 Smith, I . S., Kahn,S. N. , Lacey, B. W., King, R. H. M., Eames, R., Whybrew, D. J . & Thomas, P. K. (1983) Brain 106, 169-195